Hugh Laurie is a big blues & r'n'b fan, he has just launched his CD of New Orleans inspired stuff.
When on Jools Holland's programme he summed up how the blues affected him & pretty well took the words out of my mouth..."When I first heard the music of Muddy Waters, it was if I had always known that it existed". He is a massive fan of Otis Spann.
I seem to remember there was a discussion about blues/blues harp on House, with Wilson, in an earlier series & James Cotton got a mention.
From Wikipedia; Musical ability - Laurie plays the piano, guitar, drums, harmonica and saxophone. He has displayed his musical talents in episodes of several series, most notably A Bit of Fry & Laurie, Jeeves and Wooster, House and when he hosted Saturday Night Live in October 2006. He is a vocalist and keyboard player for the Los Angeles charity rock group Band From TV. Additionally, following Meat Loaf's appearance in the House episode "Simple Explanation," Laurie played piano as a special guest on the song "If I Can't Have You" from Meat Loaf's 2010 album Hang Cool Teddy Bear. He has played several classic Rock 'n Roll instruments on various episodes of House including both a Gibson Flying V and Les Paul. He has a Hammond B-3 Organ in his home. On one episode he performed the introduction to Procol Harum's classic "Whiter Shade of Pale." [16] Laurie appears as a scientist/doctor in the pop video to accompany Kate Bush's song Experiment IV.
Here's a background clip on the making of the album
Nice arrangements, and a great band. Sounds good to me if not totally convinced by his voice - I think he sounds best on the ballad at the end of the clip.